I mentioned the new CLARITY clearing method from Karl Deisseroth’s lab in one of my weekly paper roundups a while back and I’ve finally had a chance to read through it more carefully.
CLARITY cleared brain
Not only is it an impressive piece of work, but they have put together a nice website with detailed protocols and parts lists for building your own system. I’m considering putting one together at the NIC. I’m very curious to see what people are going to do with these techniques as they become available, but also a little terrified by the amount of microscopy data we’ll be able to generate with them.